Skip to main content
NACFC 2023 Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Livestream
Livestream
Ticketed Session
Ticketed Session
Recorded Session
Recorded Session

PTAC/CFTR
Workshop

W31--Fundamental Discoveries to Elucidate CFTR Cell Biology & Ion Transport

Saturday, November 4, 2023
7:15 AM - 9:15 AM MST
Location:105 C (West)

Recorded Session

CF-causing variants can elicit a number of defects in CFTR biogenesis such as mRNA degradation, polypeptide truncation, protein misfolding, and aberrant channel gating. Moreover, impact of cellular heterogeneity on dysfunction and rescue of mutant CFTR remains poorly understood. This workshop reports novel therapeutic targets for alleviating CFTR premature termination codons and processing variants, together with new approaches for studying mucosal cell biology and precision medicine.

Learning Objectives:

  • Describe the role of ribosome quality control during protein translation, and ways in which this pathway may be manipulated to increase synthesis of full-length CFTR.
  • Define alternative mechanisms of CFTR gating and potentiation.
  • Examine CFTR function in endothelia and airway epithelia using mouse explants and well differentiated human induced pluripotent stem cells.

Presentations:

  • 7:15 AM - 9:15 AM MST
    W31.1- Cryo-EM studies of human CFTR folding and conformational dynamics elucidate a novel potentiator binding site in the nucleotide binding domains that supports an alternative channel-gating mechanism

    Speaker: John F. Hunt, PhD (he/him/his) – Columbia Iniversity

  • 7:15 AM - 9:15 AM MST
    W31.2- Mechanism of CFTR modulation on endothelial mechanosensitive channels

    Speaker: Jean-Pierre A. Amoakon, Bachelor's – University of Cincinnati/ Cedars-Sinai Medical Center

  • 7:15 AM - 9:15 AM MST
    W31.3- eRF1 degrader SRI-41315 triggers the ribosome quality control E3 ligase network

    Speaker: Kari Thrasher (she/her/hers) – Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL

  • 7:15 AM - 9:15 AM MST
    W31.4- iPSC-based airway epithelialplatform for investigating personalized responses to CFTR modulators

    Speaker: Cristina Barillà, PhD – University of Alabama at Birmingham

  • 7:15 AM - 9:15 AM MST
    W31.5- Autofluorescence imaging allows label free identification of all airway epithelial cell types and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs)

    Speaker: Viral S. Shah, MD, PhD (he/him/his) – MGH